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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2000 | AM095 | LPA Receptor , LPL Receptor | |
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. | |||
T17183 | TY-52156 | S1P Receptor , LPL Receptor | |
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). | |||
T12821 | S1PR1 modulator 1 | LPL Receptor | |
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6. | |||
T9464 | CYM50358 | LPL Receptor | |
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM. | |||
T7360 | GSK2018682 | S1P Receptor , LPL Receptor | |
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). | |||
T7393 | ONO-7300243 | LPA Receptor , LPL Receptor | |
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM). | |||
T6347 | Ki16198 | LPA Receptor , LPL Receptor | |
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ... | |||
T15629 | JTE-013 | Apoptosis , S1P Receptor , LPL Receptor | |
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively). | |||
TQ0227 | Etrasimod | APD334 | S1P Receptor , LPL Receptor |
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells). | |||
T22834 | H2L 5765834 | LPA Receptor , LPL Receptor | |
H2L 5765834 is a lysophosphatidic acid receptors antagonist | |||
T22703 | CYM-5520 | CYM 5520 | S1P Receptor , LPL Receptor |
CYM-5520 is a noncompetitive allosteric agonist of S1P2 | |||
T15032 | CYM50308 | S1P Receptor , LPL Receptor | |
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more sel... | |||
T12086 | Mocravimod hydrochloride | KRP-203 | Others , LPL Receptor |
Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1). | |||
T28169 | NIBR-0213 | NIBR 0213 | LPL Receptor |
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. | |||
T6108 | Ki16425 | Debio 0719 | LPA Receptor , LPL Receptor |
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively. | |||
T22101 | ML-031 | S1P Receptor | |
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay. | |||
T3258 | Ponesimod | ACT-128800 | S1P Receptor , LPL Receptor |
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity. | |||
T4031 | S1p receptor agonist 1 | S1p-receptor-agonist-1 | S1P Receptor , LPL Receptor |
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist. | |||
T9699 | TAK-615 | LPA Receptor | |
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors. | |||
T15031 | CYM50260 | Others , LPL Receptor | |
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |